Synthetic lipid A derivative

摘要

The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for synthesizing and using a synthetic lipid A derivative.

主权项

1. A compound having formula I: wherein: R1 is an anomeric protecting group; R2 is azido; R3 is H or allyloxycarbonate (Alloc); R4 is a hydroxyl protecting group; R5 is —NHR11, wherein R11 is fluorenylmethoxycarbamate (Fmoc) or 2,2,2-trichloroethoxycarbonyl (Troc); R6 is H, allyloxycarbonate (Alloc) or levulinate (Lev); provided that when R6 is H, R3 is allyloxycarbonate (Alloc); and R7 and R8 are each independently H, a phosphate, a substituted phosphate, a hydroxyl protecting group, or together form a ring.