发明名称 |
UNIVERSAL PLATFORM FOR TARGETING THERAPIES TO TREAT NEUROLOGICAL DISEASES |
摘要 |
The present invention provides a universal delivery platform of functional, heterologous compounds to specific cells using toxins modified to include a heterologous compound. In one embodiment, the toxin is an AB5 toxin. In one embodiment, the AB5 toxin is a heat-labile enterotoxin from E. coli (LT), including LTI, LTII, LTIIa, LTIIb, LTIIc and other recombinant forms of LT. Methods of use are also provided. |
申请公布号 |
CA2959436(A1) |
申请公布日期 |
2016.04.07 |
申请号 |
CA20152959436 |
申请日期 |
2015.09.29 |
申请人 |
THE MEDICAL COLLEGE OF WISCONSIN, INC.;WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
BARBIERI, JOSEPH T.;CHEN, CHEN;PRZEDPELSKI, AMANDA;JOHNSON, ERIC A.;PELLETT, SABINE |
分类号 |
A61K39/116;A61K39/106;C07K1/00 |
主分类号 |
A61K39/116 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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