发明名称 |
Engineering Of A Novel Breast Tumor Microenvironment On A Microfluidic Chip |
摘要 |
A microfluidic device for more accurately modeling the in vitro environment in which cancer occurs is disclosed. The device comprises a surface defining one or more microfluidic channels that may further comprise one or more endothelial cells, a first three dimensional scaffold comprising one or more cancer cells that is spatially separated from the one or more microfluidic channels, and a second three dimensional scaffold comprising one or more stromal cells, at least a portion of which is interposed between the one or more microfluidic channels and the first three dimensional scaffold. The second three dimensional scaffold is in fluid communication with both the first three dimensional scaffold and the one or more microfluidic channels. The device can be used to assay anti-cancer agents, or as a system for modeling the growth, behavior, or metastasis and tumor formation of cancer cells. |
申请公布号 |
US2016097027(A1) |
申请公布日期 |
2016.04.07 |
申请号 |
US201514872920 |
申请日期 |
2015.10.01 |
申请人 |
Nikkhah Mehdi;Kamm Roger D.;Truong Danh |
发明人 |
Nikkhah Mehdi;Kamm Roger D.;Truong Danh |
分类号 |
C12M3/06;C12M1/00;C12M1/12 |
主分类号 |
C12M3/06 |
代理机构 |
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代理人 |
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主权项 |
1. A microfluidic device, comprising:
a surface defining one or more microfluidic channels; a first three dimensional scaffold comprising one or more cancer cells that is spatially separated from the one or more microfluidic channels; and a second three dimensional scaffold, at least a portion of which is interposed between the one or more microfluidic channels and the first three dimensional scaffold, and which is in fluid communication with both the first three dimensional scaffold and the one or more microfluidic channels. |
地址 |
Scottsdale AZ US |