Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.
申请公布号
AU2014329567(A1)
申请公布日期
2016.04.07
申请号
AU20140329567
申请日期
2014.10.02
申请人
MERCK SHARP & DOHME CORP.
发明人
LIN, SONGNIAN;YAN, LIN;KEKEC, AHMET;ZHU, YUPING;HUNTER, DAVID N.;HUO, PEI;FENG, DANQING;NARGUND, RAVI P.;MOYES, CHRISTOPHER R.;ZHAO, ZHIQIANG;PIPIK, BRENDA;PISSARNITSKI, DMITRI;DUFFY, JOSEPH L.;GUIDRY, ERIN N.