| 发明名称 | Natural combination hormone replacement formulations and therapies | ||
| 摘要 | Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone. | ||
| 申请公布号 | US9301920(B2) | 申请公布日期 | 2016.04.05 |
| 申请号 | US201313843428 | 申请日期 | 2013.03.15 |
| 申请人 | TherapeuticsMD, Inc. | 发明人 | Bernick Brian A.;Cacace Janice Louise;Persicaner Peter H. R.;Irani Neda;Amadio Julia M. |
| 分类号 | A01N45/00;A61K31/56;A61K9/00;A61K31/57;A61K31/565;A61K47/44;A61K9/48;A61K47/10;A61K47/14;A61K9/107;A61K9/02 | 主分类号 | A01N45/00 |
| 代理机构 | Kilpatrick Townsend & Stockton LLP | 代理人 | Kilpatrick Townsend & Stockton LLP |
| 主权项 | 1. A pharmaceutical formulation for administering estradiol and progesterone to a mammal in need thereof, comprising solubilized estradiol, solubilized progesterone, suspended progesterone, and an oil, wherein each of the solubilized estradiol, the solubilized progesterone, and the suspended progesterone is present in the oil, and wherein the oil comprises medium chain fatty acid esters of glycerol, polyethylene glycol, or propylene glycol, or mixtures thereof, wherein the medium chain fatty acid esters are predominantly esters of C6 to C12 fatty acids. | ||
| 地址 | Boca Raton FL US | ||