| 发明名称 | Stable formulations for parenteral injection of peptide drugs | ||
| 摘要 | Stable formulations for parenteral injection of peptide drugs and methods of using such stable formulations are provided. In particular, the present invention provides stable formulations for parenteral injection of glucagon and methods of using such glucagon formulations to treat hypoglycemia, especially severe hypoglycemia in emergency situations. | ||
| 申请公布号 | US9302010(B2) | 申请公布日期 | 2016.04.05 |
| 申请号 | US201414188464 | 申请日期 | 2014.02.24 |
| 申请人 | Xeris Pharmaceuticals, Inc. | 发明人 | Prestrelski Steven;Kinzell John |
| 分类号 | A61K38/29;A61K38/22;A61K38/26;A61K38/28;A61K47/26;A61K9/00;A61K9/19;A61K47/02;A61K47/10;A61K47/12;A61K47/14;A61K47/18;A61K47/20;A61K47/22;A61K38/09;A61K38/16;A61K38/17;A61K38/18;A61K38/25;A61K38/30;A61K38/48 | 主分类号 | A61K38/29 |
| 代理机构 | Norton Rose Fulbright US LLP | 代理人 | Norton Rose Fulbright US LLP |
| 主权项 | 1. A stable solution for parenteral injection comprising: (a) a glucagon peptide or a salt thereof that has been dried from a non-volatile buffer; and (b) an aprotic polar solvent, wherein the glucagon peptide or salt thereof is reconstituted and solubilized in the aprotic polar solvent in an amount from about 0.1 mg/mL up to the solubility limit of the glucagon peptide or salt thereof; wherein the glucagon peptide or salt thereof has a pH memory. | ||
| 地址 | Austin TX US | ||