| 主权项 |
1. A compound having the formula (I): wherein X is carbon, —NH(H+Cl−), alkylene, or alkyleneamino; R1 is hydrogen, deuterium, halo, hydroxyl, nitro, guanidinyl, —(R6)-guanidine, fonnamidinyl, carbonyl, oxime, amino, aminocarbonyl, aminooxy, aralkoxy, or aralkylaminooxy; R2 and R3 are each independently hydrogen, deuterium, hydroxyl, carbonyl, amino, nitro, alkyl, trifluoromethyl, aryl, aminocarbonyl, or —C(═Y)—Z, or R2 and R3 taken together along with the atom to which they are both attached form a six-membered carbocyclic ring or a dithanyl ring optionally substituted with up to three substituents independently selected from alkyl, aryl, aralkyl, hydroxyl, nitro, amino, andcarbonyl;
Y is O, S, or NH; Z is amino, —NH—NH2, methyloxy, or methylthio; R4 is hydrogen, deuterium, or amino; R5 is hydrogen or carbonyl; and, R6 is —CH(CH3)— or —NH—C(═NH)—; or a stereoisomer, partial stereoisomer, prodrug, pharmaceutically acceptable salt, hydrate, solvate, acid hydrate, or N-oxide thereof, with the proviso that if R1 is amino and X is methylene or ethylene, R2, R3, R4, and R5 cannot all be hydrogen. |
