METHOD FOR PREDICTING THE RESPONSE TO HER2-DIRECTED THERAPY

摘要

This invention provides methods for determining or predicting response to HER2-directed therapy in an individual.

主权项

1. A method for identifying a mammalian tumor that responds to a HER2-directed therapy, wherein the mammalian tumor overexpresses HER2, the method comprising the step of assaying a sample obtained from the mammalian tumor to detect a pattern of expression, phosphorylation or both expression and phosphorylation of one or a plurality of polypeptides consisting of:
(a) IGFR polypeptide; (b) EGFR polypeptide; (c) NDF polypeptide; (d) phosphorylated S6 ribosomal polypeptide; (e) phosphorylated AKT polypeptide; and (f) phosphorylated ERK polypeptide; wherein the detected pattern of expression, phosphorylation or both expression and phosphorylation identifies mammalian tumors that respond to a HER2-directed therapy.