| 发明名称 |
Molecular Targets for Cardiovascular Disease |
| 摘要 |
The invention relates to methods and compositions for treating and preventing cardiovascular disease, including but not limited to treating and preventing endothelial dysfunction in subjects having hyperhomocysteinemia, hyperglycemia, or a combination of hyperhomocysteinemia and hyperglycemia. As endothelial dysfunction is an indicator for atherosclerosis and cardiovascular disease, this treatment has general impact for early prevention and treatment for all cardiovascular disease. In particular, the present invention relates to methods and compositions for inhibiting calpain activity. |
| 申请公布号 |
US2016089391(A1) |
申请公布日期 |
2016.03.31 |
| 申请号 |
US201514864000 |
申请日期 |
2015.09.24 |
| 申请人 |
Temple University-of the Commonwealth System of Higher Education |
发明人 |
Wang Hong |
| 分类号 |
A61K31/713;G01N33/573;A61K38/06;A61K45/06;A61K38/05 |
主分类号 |
A61K31/713 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method for treating endothelial dysfunction in a subject having hyperhomocysteinemia, hyperglycemia, or a combination of hyperhomocysteinemia and hyperglycemia, the method comprising administering to the subject a therapeutically effective amount of a composition comprising at least one inhibitor of calpain. |
| 地址 |
Philadelphia PA US |
