发明名称 | Substituted isoindoline-1,3-dione derivatives | ||
摘要 | This invention relates to novel substituted isoindoline-1,3-dione derivatives and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel substituted isoindoline-1,3-dione derivatives that are analogs of apremilast. This invention also provides compositions comprising a compound of this invention and a carrier and the use of disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering apremilast. | ||
申请公布号 | US9296689(B2) | 申请公布日期 | 2016.03.29 |
申请号 | US201414490859 | 申请日期 | 2014.09.19 |
申请人 | Concert Pharmaceuticals, Inc. | 发明人 | Liu Julie F. |
分类号 | C07D209/48;C07D207/404;C07D209/46;C07D405/12;C07B59/00 | 主分类号 | C07D209/48 |
代理机构 | McCarter & English, LLP | 代理人 | McCarter & English, LLP ;Davis Steven G.;Dertz Emily |
主权项 | 1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from CH3, CH2D, CHD2, and CD3; R2 is CH3 or CD3; R3 is selected from CH3, CH2D, CHD2, CD3, CF3, CHF2, CH2F, CDF2, and CD2F; R4 is an ethyl group substituted with zero to five deuterium, or is a cyclopentyl group substituted with zero to nine deuterium; X is C═O; each of Y1a, Y1b, Y2, Y3, Y4, Y5, Y7 and Y8 is H; and Y6 is selected from Cl, H, and D; provided that if R1 is CH3; R2 is not substituted with deuterium; R3 is CH3, CF3, CHF2, or CH2F; and Y6 is Cl or H; then R4 is an ethyl group substituted with one to five deuterium or a cyclopentyl group substituted with one to nine deuterium. | ||
地址 | Lexington MA US |