发明名称 |
composição imunogênica, seu método de fabricação, método de fabricação de uma composição de vacina de matriz de proteína, e uso |
摘要 |
The present invention relates to immunogenic compositions containing an antigen of interest entrapped with a crosslinked carrier protein matrix, methods of making such vaccines, and methods of vaccine administration, wherein the immunogenicity of the protein matrix, and hence its effectiveness as a vaccine, is improved by controlling or selecting the particle size of the protein matrix particles to eliminate low molecular weight particles, e.g., less than 100 nm in diameter. |
申请公布号 |
BR112012005349(A2) |
申请公布日期 |
2016.03.29 |
申请号 |
BR20121105349 |
申请日期 |
2010.09.09 |
申请人 |
MATRIVAX RESEARCH & DEVELOPMENT CORP. |
发明人 |
ANN THANAWASTIEN;KEVIN P. KILLEEN;THOMAS J. GRIFFIN, IV |
分类号 |
A61K39/09;A61K39/00;A61K39/112 |
主分类号 |
A61K39/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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