CHIMERIC ANTIBIOTICS BASED ON AZITHROMYCIN AND GLYCOPEPTIDE ANTIBIOTICS, HAVING ANTIBACTERIAL ACTIVITY AND SYNTHESIS METHOD THEREOF

摘要

FIELD: medici≠ pharmaceuticals.SUBSTANCE: disclosed are compounds of formula 2, where n=1-10, and R is a fragment of vancomycin, eremomycin or teicoplanin aglycone. Method for preparing compounds of formula 2 comprises conducting acylation reaction 11-O-(ω-aminoalkylcarbamoyl)azithromycin (6) with glycopeptide antibiotic (eremomycin or vancomycin, or teicoplanin aglycone) in presence of a condensing agent.EFFECT: invention relates to novel derivatives of azithromycin and a method for production thereof, which can be used in pharmaceutical industry and medicine.2 cl, 4 dwg, 2 ex, 2 tbl