发明名称 METABOLIC IMPRINTING EFFECTS OF SPECIFICALLY DESIGNED LIPID COMPONENT
摘要 The invention relates to the use of specifically designed lipid component with optimal fatty acid profile, an enhanced portion of the palmitic acid residues in the sn-2 position and present as lipid globules with a phospholipid coating for an early in life diet for improving the development of a healthy body composition, in particular prevention of obesity, later in life.
申请公布号 US2016081963(A1) 申请公布日期 2016.03.24
申请号 US201514954370 申请日期 2015.11.30
申请人 N.V. Nutricia 发明人 VAN DER BEEK Eline Marleen;ABRAHAMSE-BERKEVELD Marieke;OOSTING Annemarie;ALLES Martine Sandra
分类号 A61K31/202;A61K31/20;A23L1/30;A61K31/7016;A23L1/48;A23L1/29;A61K31/201;A61K35/20 主分类号 A61K31/202
代理机构 代理人
主权项 1. A method of prevention of obesity, reducing the risk of obesity, treatment of obesity, prevention of diabetes type 2, reducing the risk of occurrence of insulin resistance and improving insulin sensitivity, preventing metabolic syndrome, comprising administering to a subject in need thereof a nutritional composition comprising carbohydrates, protein and lipid, wherein the lipid is present in the form of lipid globules comprising: (a) linoleic acid and alpha-linolenic acid in a weight ratio of 2 to 10, (b) at least 10 wt. % palmitic acid based on total fatty acids, wherein at least 30 wt. % of the palmitic acid is esterified to the sn-2 position of a triglyceride based on total palmitic acid, and (c) a surface at least partly coated with phospholipids, wherein the amount of phospholipids present in the nutritional composition being from 0.5 to 20 wt. % phospholipids based on total lipid, and wherein the nutritional composition is not human milk.
地址 Zoetermeer NL