SYSTEM AND METHOD FOR EFFICIENT DETECTION OF THE PHASE AND AMPLITUDE OF A PERIODIC MODULATION ASSOCIATED WITH SELF-INTERFERING FLUORESCENCE

摘要

Systems and methods according to exemplary embodiments of the present disclosure can be provided that can efficiently detect the amplitude and phase of a spectral modulation. Such exemplary scheme can be combined with self-interference fluorescence to facilitate a highly sensitive depth localization of self-interfering radiation generated within a sample. The exemplary system and method can facilitate a scan-free depth sensitivity within the focal depth range for microscopy, endoscopy and nanoscopy.

主权项

1. An apparatus which is configured to obtain at least one electro-magnetic radiation from at least one portion of a sample, comprising:
at least one optical first arrangement which is configured to receive the at least one electro-magnetic radiation from the at least one portion, and generate at least one first radiation based on the at least one electro-magnetic radiation, wherein the at least one electro-magnetic radiation is separated and recombined to be self-interfered after exiting the at least one portion; at least one interference second arrangement which is configured to receive and further separate and recombine the first radiation so as to further self-interfere and generate at least one second radiation; and at least one computer third arrangement which is configured to determine information regarding the at least one portion based on the at least one second radiation.