SUBSTITUTED TRIAZINE KINASE INHIBITORS

摘要

The present invention provides substituted 1,3,5-triazine compounds of Formula (I):
wherein
X, Y and Z are independently selected from the group consisting of CH and N; wherein m is an integer from 2 to 5; wherein X, Y and Z include at least one CH atom and at least one N atom; and, wherein a N atom may simultaneously occupy only the X and Z positions;
R 1 is selected from the group consisting of hydrogen and NH 2 ; and,
R 2 is selected from the group consisting of phenyl (wherein phenyl is substituted with one substituent selected from the group consisting of halogen and heterocyclyl) and 1,4-benzodioxinyl;
and pharmaceutically acceptable salts thereof as kinase inhibitors and a method for treating or ameliorating a kinase mediated disorder.