| 主权项 |
1. A method of treating HPV infected cells comprising contacting the cells with an effective amount of a polyamide compound of the formula:
Im-(X)n-γq-(X)m-Y-A or a pharmaceutically acceptable salt thereof, wherein m is 10 or 11; n is 9 or 10; Im is desamino-imidazole; each X is independently selected from 4-amino-2-carbonyl-N-methylimidazole (I), 4-amino-2-carbonyl-N-methylpyrrole (P) or β-alanine (β), subject to the proviso that the compound contains no more than two I units; γq is γ-amino butyric acid (γ), (S)-2,4-diaminobutyric acid, (R)-2,4-diaminobutyric acid (γNH2), (S)-2-(acetylamino)-4-aminobutyric acid, or (R)-2-(acetylamino)-4-aminobutyric acid (γNHAc); Y is β-alanine (β) or 4-amino-2-carbonyl-N-methylpyrrole (P); and A is 3,3′-diamino-N-methyldipropylamine (Ta) or dimethylaminopropylamine (Dp), with the proviso that the polyamide compound is not ImPPPβPPβPPPγPPPβPPPβPPPβDp, ImPPPβPPβPPPγNH2PPPβPPPβPPPβDp, ImPPβPIPβPPγNH2PPβPPPβPPPβTa, ImPPβPIPβPPγNH2PPβPPPβPPPβDp, ImPPPPIPPPPIγPPPPPPPPPPβDp, ImPPPPPIPPPγPPPPPPPPPPβDp, or ImPPPPPPPPPPγPPPPPPPPPPPβDp. |
