发明名称 |
Urgency therapy with neuromodulation and C-afferent nerve desensitization |
摘要 |
Systems (10), devices (16), and methods may be used for treating bladder dysfunction, such as urgency and pelvic pain. In one example, a method includes administering a pharmacological agent to a patient (14) in a dosage sufficient to desensitize a C-afferent nerve fiber of the patient. Additionally, the method includes delivering stimulation to activate a nerve fiber proximate to the C-afferent nerve fiber via an electrode (19A, 19B, 21A, 21B, 29A-29D) electrically coupled to an implantable medical device (16). In some examples, the nerve fiber may be different than the C-afferent nerve fiber, the stimulation of the nerve fiber may elicit an inhibitory physiological response related to voiding in the patient, and/or the stimulation substantially may not activate the C-afferent nerve fiber after desensitization of the nerve fiber via the administration of the pharmacological agent. |
申请公布号 |
US9289607(B2) |
申请公布日期 |
2016.03.22 |
申请号 |
US201113817486 |
申请日期 |
2011.08.16 |
申请人 |
MEDTRONIC, INC. |
发明人 |
Su Xin;Molnar Gregory F.;Nelson Dwight E. |
分类号 |
A61N1/02;A61N1/36;A61M5/142;A61M5/172;G06F19/00;A61K31/165 |
主分类号 |
A61N1/02 |
代理机构 |
Shumaker & Sieffert, P.A. |
代理人 |
Shumaker & Sieffert, P.A. |
主权项 |
1. A method comprising:
administering a pharmacological agent to a patient in a dosage sufficient to desensitize a C-afferent nerve fiber of the patient; and delivering electrical stimulation to activate a nerve fiber proximate to the C-afferent nerve fiber via an electrode electrically coupled to an implantable medical device, wherein the nerve fiber is different than the C-afferent nerve fiber, wherein the stimulation of the nerve fiber elicits an inhibitory physiological response related to voiding in the patient, and wherein the stimulation substantially does not activate the C-afferent nerve fiber after desensitization of the nerve fiber via the administration of the pharmacological agent. |
地址 |
Minneapolis MN US |