STIMULATION OF IMMUNITY TO TUMOR SPECIFIC AND ENDOTHELIAL SPECIFIC PROTEINS BY IN VIVO DC ATTRACTION AND MATURATION

摘要

Treatment of cancer is disclosed through administration of proteins or specific peptides in vivo, in a matter eliciting monocyte or dendritic cell migration in order to allow uptake of said administrated proteins or peptides, followed by administration of a maturation signal in vivo. The invention provides for treatment of cancer through induction of anticancer immunity and/or immunity towards tumor associated blood vessels.

主权项

1. A method of inducing an anticancer response comprising the steps of: a) administering to a patient a tumor or tumor endothelium associated antigen; b) administering a chemoattracting agent either prior to, concurrent with, or subsequent to administration of said tumor or tumor endothelium associated antigen, said chemoattracting agent increasing number of antigen presenting cells in proximity to said tumor antigen or tumor endothelial antigen in a manner to allow uptake by said antigen presenting cells; c) allowing a period of time for antigen presenting cells to uptake said antigen, process said antigen, and migrate to a lymph node; and d) administering a maturation agent of antigen presenting cells.