发明名称 |
Agents directed against a cis RGMa/Neogenin interaction or lipid rafts and use of the same in methods of treatment |
摘要 |
Disclosed herein is an agent that modulates a cis interaction between Repulsive Guidance Molecule A (RGMa) and Neogenin or lipid rafts. Modulation by the agent may include blocking the cis interaction between RGMa and Neogenin and/or disrupting lipid rafts. In turn, this promotes neuronal cell survival and axon growth and/or regeneration. Also disclosed herein is a method of treating a disease in a subject in need thereof. The method may include administering the agent to the subject. Further disclosed herein is a method of identifying an agent that modulates the cis interaction between RGMa and Neogenin. |
申请公布号 |
AU2014324043(A1) |
申请公布日期 |
2016.03.17 |
申请号 |
AU20140324043 |
申请日期 |
2014.08.06 |
申请人 |
UNIVERSITY HEALTH NETWORK (UHN): TECHNOLOGY DEVELOPMENT AND COMMERCIALIZATION |
发明人 |
MONNIER, PHILIPPE P.;TASSEW, NARDOS G. |
分类号 |
C07K14/705;A61K31/137;A61K38/17;A61K39/395;A61P9/10;A61P25/00;C07K14/435;G01N33/53 |
主分类号 |
C07K14/705 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|