发明名称 |
RSPONDINER SOM MODULATORER AF ANGIOGENESE OG VASKULOGENESE |
摘要 |
The present invention relates to the use of Rspondins, particularly Rspondin2 (Rspo2) or Rspondin3 (Rspo3) or Rspondin nucleic acids, or regulators or effectors or modulators of Rspondin e.g. Rspo2 and/or Rspo3 to promote or inhibit angiogenesis and/or vasculogenesis, respectively. The invention is based on the demonstration that Rspo3 and Rspo2 are angiogenesis promoters, and the identification of Rspo2 and 3 as positive regulators of vascular endothelial growth factor (VEGF). These results indicate a major role for Rspondins, particularly Rspo3 and/or Rspo2 in the signalling system during angiogenesis. The invention also relates to the use regulators or effectors or modulators of Rspondin3, including agonists and antagonists, in the treatment of conditions where treatment involves inhibiting or promoting angiogenesis and/or vasculogenesis. |
申请公布号 |
DK2081586(T3) |
申请公布日期 |
2016.03.14 |
申请号 |
DK20070819170T |
申请日期 |
2007.10.19 |
申请人 |
DEUTSCHES KREBSFORSCHUNGSZENTRUM, STIFTUNG DES ÖFFENTLICHEN RECHTS |
发明人 |
KAZANSKAYA, OLGA;NIEHRS, CHRISTOF;OKAWARA, BISEI |
分类号 |
A61K38/17;A61K39/395;A61P35/00;C07K14/475;C07K14/515;C07K16/18 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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