| 摘要 |
FIELD: medicine.SUBSTANCE: method for evaluating at least one vasodilation parameter as an individual's local coetaneous thermal hyperemic response, involves taking a basic measurement in a first area of individual's samples taking at a first temperature and generating a first basic red blood cell flow (RBCF) of the sampling area and measuring an individual's first base mean arterial pressure (P), increasing a temperature of the first sampling area from the first temperature to the second temperature, maintaining the second temperature for the initial heating period making from 2 to 14 minutes, and recording a range of the first initial RBCFs (RBCF) of the first sampling area in the range of time points (T) to determine the first initial maximum RBCF (RBCF,), and recording the individual's first initial mean arterial pressure (P) during the initial heating period, and calculating the vasodilation parameter, wherein the vasodilation parameter equals to or originates from a first initial maximum coetaneous vascular conductivity (CVC) calculated by formula: CVC= RBCF/P; the vasodilation parameter derived from the first CVC, is a measurement (ΔCVC) of the first initial maximum CVC, or an initial area under curve (initial AUC); ΔCVC is calculated by formula: ΔCVC = CVC- (RBCF/P), and for initial AUC, RBCFis marked against Tto plot a curve having a curve function of F(X); initial AUC is calculated by formula:wherein t equals to or exceeds RBCFmeasurement time. A laser Doppler apparatus comprises a user interface, laser Doppler detector, heating unit to heat the sampling area, laser Doppler detector and heating unit controller based on user input and default settings, computing unit, database containing a standard vasodilation parameter measured in a group of healthy individuals, and a comparator unit used to compare the individual's vasodilation parameter to the standard value.EFFECT: using the invention enables the higher measurement efficiency.10 cl, 2 dwg, 15 tbl, 8 ex |
