发明名称 |
AMINOINDANE-, AMINOTETRAHYDRONAPHTHALENE- AND AMINOBENZOCYCLOBUTANE-DERIVED PRMT5-INHIBITORS |
摘要 |
A compound of formula (la), (lb) or (lc) wherein: n is 1 or 2; RN is H or Me; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d (if present) are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4a is selected from OH, -NH2, -C(=O)NH2, and -CH2OH; R4b is either H or Me; R5 is either H or Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl. |
申请公布号 |
WO2016034671(A1) |
申请公布日期 |
2016.03.10 |
申请号 |
WO2015EP70146 |
申请日期 |
2015.09.03 |
申请人 |
CTXT PTY LTD |
发明人 |
BERGMAN, YLVA ELISABET;LESSENE, ROMINA;GANAME, DANNY;FOITZIK, RICHARD CHARLES;MORROW, BENJAMIN JOSEPH;CAMERINO, MICHELLE ANG;WALKER, SCOTT RAYMOND;LAGIAKOS, H. RACHEL;FEUTRILL, JOHN;STUPPLE, PAUL ANTHONY |
分类号 |
C07D403/12;A61K31/397;A61K31/40;A61K31/4245;A61K31/435;A61K31/4458;A61P35/00;A61P35/02;C07C233/78;C07D205/04;C07D231/12;C07D271/10;C07D295/185;C07D401/12;C07D405/12 |
主分类号 |
C07D403/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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