PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF METABOLIC DISORDERS

摘要

The invention relates to a pharmaceutical combination comprising the compound of formula I;;or pharmaceutically acceptable salts thereof in combination with at least one second therapeutic agent 2. The pharmaceutical combination of the invention is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.

主权项

1. A method of improving glycemic control in a patient with type 2 diabetes for whom monotherapy with metformin is contraindicated and/or who has an intolerance against metformin at therapeutic doses, the method comprising administering to a patient in need thereof a pharmaceutical combination comprising a compound of formula (I) or pharmaceutically acceptable salts thereof in combination with at least one second therapeutic agent 2 selected from the group consisting of metformin (2.a1), glimepiride (2.b6), sitagliptin (2.g4), linagliptin (2.g7), and 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene (2.h9).