| 发明名称 | Method of identifying patients not suitable for high-dose cyclophosphamide treatment | ||
| 摘要 | The present invention provides methods of identifying subjects that are suitable and not suitable for high-dose cyclophosphamide treatment. | ||
| 申请公布号 | US9279803(B2) | 申请公布日期 | 2016.03.08 |
| 申请号 | US201113240443 | 申请日期 | 2011.09.22 |
| 申请人 | The Johns Hopkins University;Accentia Biopharmaceuticals, Inc. | 发明人 | Brodsky Robert A.;Jones Richard J.;O'Donnell, Jr. Francis E.;Bonitz Susan;Kaplin Adam;Santos Carlos |
| 分类号 | G01N33/50;G01N33/94;C12Q1/32 | 主分类号 | G01N33/50 |
| 代理机构 | Foley Hoag LLP | 代理人 | Foley Hoag LLP |
| 主权项 | 1. A method for identifying a subject suitable for high-dose cyclophosphamide treatment, comprising measuring the amount or activity of aldehyde dehydrogenase (ALDH) from peripheral lymphocytes from a sample from said subject, wherein the subject is identified as being suitable for high-dose cyclophosphamide treatment if the amount or activity of ALDH is less than the amount or activity of ALDH which confers resistance of the peripheral lymphocytes to high-dose cyclophosphamide treatment, and administering cyclophosphamide to the subject. | ||
| 地址 | Baltimore MD US | ||