GERANYL FLAVONOID DERIVATIVE WITH IMPROVED WATER SOLUBILITY, A METHOD FOR PREPARING THE SAME, AND A METHOD FOR TREATING CANCER USING THE SAME

摘要

The present invention relates to a novel geranyl flavonoid derivative with improved water-solubility or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a method for treating cancer using the same. Particularly, the novel geranyl flavonoid derivative of the present invention inhibits the expression of STAT3 target protein by suppressing the phosphorylation of STAT3 (Signal Transducers and Activators of Transcription 3) protein, suggesting that it has cancer cell growth inhibiting effect in various cancer cell lines. Also, the compound of the invention has the effect of reducing the size and weight of a tumor significantly in vivo, so that the geranyl flavonoid derivative or the pharmaceutically acceptable salt thereof can be efficiently used for the treatment of cancer.

主权项

1. A geranyl flavonoid derivative represented by formula 1 or a pharmaceutically acceptable salt thereof: wherein, R is a C1-3 linear or branched chain alkoxy group; a C1-4 linear or branched chain alkyl carbonyl group; a substituted or unsubstituted 6-membered heterocycloalkyl carbonyl group comprising one or two heteroatoms selected from the group consisting of O and N; a substituted or unsubstituted C4-10 heteroaryl comprising one or more Ns; a substituted or unsubstituted C6-10 aryl sulfonyl; or a dimethylamino C1-3 linear or branched chain alkyl, wherein the substituted 6 membered heterocycloalkyl, substituted C4-10 heteroaryl and substituted C6-10 aryl may be independently substituted by one or more C1-4 linear or branched alkyl.