Osteoinductive nanocomposites

摘要

The present invention relates porous osteoinductive nanocomposites and for the methods to prepare osteoinductive nanocomposites. The osteoinductive composites consist of biocompatible polymers and non-heated (or non-sintered), needle-shaped or plate-like calcium phosphate nanocrystals and the methods comprise the steps of: a. adding phosphate to a calcium solution thereby evoking precipitation of calcium phosphate nanocrystals; b. washing the nanocrystals with water and suspending them in an organic solvent or getting dry calcium phosphate nanocrystals after evaporating organic solvent; c. adding polymers (previously dissolved in an organic solvent) to calcium phosphate nanocrystal suspension, rotational mixing of the components using beads, mixing with porogenic agents, moulding the composite material and evaporating of the organic solvent; or mixing polymers (not dissolved in an organic solvent but raw powder), dry calcium phosphate nanocrystals and porogenic agents with melting intrusion and moulding the composites; d. leaching porogenic agents in water.

主权项

1. A porous osteoinductive composite material comprising a biocompatible polymer, at least 20 wt.% by weight of the total composition of calcium phosphate nanocrystals, wherein said calcium phosphate nanocrystals are non-heated and non-sintered amorphous non-stoichiometric calcium phosphate crystals, wherein said calcium phosphate nanocrystals have needle-shaped or plate-shaped crystals having a width of about 5-200 nm, said composite having a porosity of at least 10% and having pores with a pore size of at least 50 μm.