Risk factors and prediction of myocardial infarction

摘要

Biomarkers and methods are disclosed for diagnosing the risk of a myocardial infarction in an individual by measuring the levels of a set of biomarkers in a sample from an individual. A risk score is calculated for the individual by weighting the measured levels of the biomarkers. The risk score then is used to identify whether the individual is likely to experience a myocardial infarction. In addition, kits are disclosed that include a set of reagents for specifically measuring biomarker levels in a sample from an individual.

主权项

1. A method of diagnosing the risk of a future myocardial infarction in an individual, the method comprising:
measuring the level of each biomarker of a set of biomarkers in a sample from an individual, wherein each biomarker of the set of biomarkers is measured using a respective antibody that specifically measures the biomarker and the set of biomarkers comprises:
(i) carcinoembryonic antigen, beta-2 microglobulin and transferrin; and(ii) at least one of N-terminal pro B-type natriuretic peptide, alpha-1 antitrypsin, and C-reactive protein; calculating a risk score for the individual by weighting the measured levels of the biomarkers, wherein calculating a risk score comprises: transforming logarithmically the measured levels of the biomarkers to generate a transformed value for each measured biomarker; multiplying the transformed value of each biomarker by a biomarker constant to generate a multiplied value for each biomarker; and summing the multiplied value of each biomarker to generate the risk score; and using the risk score to identify a likelihood that the individual will experience a myocardial infarction in the future.