| 摘要 |
Disclosed are: a composition comprising a double-stranded nucleic acid molecule and a liposome in which the double-stranded nucleic acid molecule is encapsulated; and others. In the composition, the double-stranded nucleic acid molecule comprises an antisense strand and a sense strand, wherein the antisense strand is a polynucleotide which contains a nucleotide sequence complementary to a sequence composed of contiguous 17 nucleotides contained in mRNA for a target gene and which has a length of 17 to 30 nucleotides, the sense strand is a polynucleotide which contains a nucleotide sequence complementary to a sequence lying between the 1st nucleotide and the 17th nucleotide numbered from the 5'-terminal toward the 3'-terminal in the antisense strand and which has a length of 17 to 30 nucleotides, each of sugars respectively bound to a nucleotide located at a specific position in the antisense strand and a nucleotide located at a specific position in the sense strand is a deoxyribose or a ribose in which a hydroxy group at position-2' is substituted by a modifying group, and the deoxyribose and the ribose are contained at a specific ratio. In the composition, the liposome has a lipid bilayer membrane comprising a lipid derivative, fatty acid derivative or aliphatic hydrocarbon derivative of a water-soluble substance as a component. |
