Timing control for paired plasticity

摘要

Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training. Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury and post-traumatic stress disorder.

主权项

1. A system, comprising:
a timing control system configured to treat tinnitus therapy comprising:
a sound generator configured to generate a plurality of sounds;an implantable vagus nerve stimulator configured to stimulate a vagus nerve of a patient, wherein the timing control system is configured to synchronize stimulation of the vagus nerve with the generation of the plurality of sounds, the implantable vagus nerve stimulator includes an electrode and a pulse generator connected to the electrode, wherein the implantable vagus nerve stimulator is configured to stimulate a vagus nerve of a patient in contact with the electrode with an electrical pulse train from the pulse generator, the system is configured to receive data defining frequencies corresponding to that associated with a patient's tinnitus, and the system is configured to instruct the sound generator to generate a series of the sounds such that the sounds do not have frequencies corresponding to those associated with the patient's tinnitus.