Inhibidores del canal de potasio de la médula externa renal
摘要
This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.
申请公布号
ES2561654(T3)
申请公布日期
2016.02.29
申请号
ES20100716982T
申请日期
2010.04.29
申请人
Merck Sharp & Dohme Corp.
发明人
PASTERNAK, Alexander;SHAHRIPOUR, Aurash;TANG, Haifeng;TEUMELSAN, Nardos H.;YANG, Lihu;ZHU, Yuping;WALSH, Shawn P.