| 发明名称 |
SMALL COMPOUNDS TARGETING TACC3 |
| 摘要 |
The present invention provides a small compound targeting at TACC3. The present invention further provides a drug, particularly, an anticancer agent, comprising the small compound targeting at TACC3. A compound represented by the general formula (I) or a pharmaceutically acceptable salt, solvate, or ester derivative thereof binds to TACC3 and inhibits cell growth. Thus, these compounds can be used as drugs, particularly, anticancer agents. |
| 申请公布号 |
US2016052918(A1) |
申请公布日期 |
2016.02.25 |
| 申请号 |
US201514865076 |
申请日期 |
2015.09.25 |
| 申请人 |
JAPANESE FOUNDATION FOR CANCER RESEARCH |
发明人 |
Yao Ryoji;Osada Hiroyuki;Kondoh Yasumitsu |
| 分类号 |
C07D405/14;C07D311/16 |
主分类号 |
C07D405/14 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof for use in the treatment of a cancer targeting at TACC3 and/or a TACC3-TOGp complex: wherein R1 represents OAc, NEt2, NMe(CH2CH2OH), NH(CH2CH2NMe2), NEt(CH2CH2NMe2), N(CH2CH2OMe)2, N+O−(CH2CH2OMe)2, NMe(CH2)3Me, or N(CH2CH2Me)2; R2 represents Ac or H; and R3 represents H, Cl, F, or Br. |
| 地址 |
Tokyo JP |
