Peristaltic Pump Microfluidic Separator

摘要

A technique for separating components of a microfluid, comprises a self-intersecting micro or nano-fluidic channel defining a cyclic path for circulating the fluid over a receiving surface of a fluid component separating member; and equipment for applying coordinated pressure to the channel at a plurality of pressure control areas along the cyclic path to circulate the fluid over the receiving surface, applying a pressure to encourage a desired transmission through the separating member, and a circulating pressure to remove surface obstructions on the separating member. The equipment preferably defines a peristaltic pump. Turbulent microfluidic flow appears to be produced.

主权项

1. A microfluidic separator comprising a peristaltic pump coupled to a source and a retentate channel, a fluid component separating member, and a filtrate outlet, wherein:
the peristaltic pump comprises at least three pressure control areas interconnected by at least one microfluidic or nanofluidic channel overlying the separating member, the at least one channel and pressure control areas defining a closed microfluidic circuit; and the separating member is located between the peristaltic pump and filtrate outlet with a first surface of the separating member coupled with the at least one channel, and a second surface of the separating member coupled with the filtrate outlet to selectively permit fluid components to pass from the at least one channel to the filtrate outlet.