ANTI-ANGIOGENIC PEPTIDES AND USES THEREOF

摘要

Provided are peptide sequences derived from prostate serum antigen (PSA). The peptides are provided in cyclic and linear form. Methods for using the peptides for inhibition of angiogenesis, such as angiogenesis in a tumor, are provided.

主权项

1. A method of inhibiting angiogenesis in an individual comprising inhibiting angiogenesis in the individual by administering a composition comprising a peptide to the individual in an amount effective to inhibit the angiogenesis, wherein the peptide is selected from the group consisting of: Lys Asn Arg Phe Leu Arg Pro Gly Asp Asp Ser Ser His (SEQ ID NO:1), Cys Lys Asn Arg Phe Leu Arg Pro Gly Asp Asp Ser Ser His Cys (SEQ ID NO:7), Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val Thr Lys (SEQ ID NO:3), Val Ala Ala Gln Val His Pro Gln Lys Val Thr Lys (SEQ ID NO:8), Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val Thr Lys Phe Met Leu Cys Ala (SEQ ID NO:6), Asn Asp Val Ala Ala Gln Val His Pro Gln Lys Val Thr Lys Phe Met Leu Ala Ala (SEQ ID NO:9), and combinations thereof.