发明名称 |
RECOMBINANT HUMAN ANTIBODIES FOR THERAPY AND PREVENTION OF POLYOMAVIRUS-RELATED DISEASES |
摘要 |
Provided are novel human-derived antibodies specifically recognizing polyomavirus polypeptides, preferably capable of binding to polyomaviruses of the type of JC virus (JCV) and/or BK virus (BKV) as well as methods related thereto. Furthermore, assays and kits related to antibodies specific for polyomaviruses, polyomavirus VP1 and or polyomavirus VP1 Virus-Like Particles (VLPs), preferably of the type of JCV and/or BKV, are disclosed. The human-derived antibodies as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for polyomavirus targeted immunotherapy and diagnostics. |
申请公布号 |
US2016052996(A1) |
申请公布日期 |
2016.02.25 |
申请号 |
US201414758615 |
申请日期 |
2014.01.02 |
申请人 |
NEURIMMUNE HOLDING AG ;UNIVERSITY OF ZURICH |
发明人 |
GRIMM Jan;MARTIN Roland;COMBALUZIER Benoit;JELCIC Ivan |
分类号 |
C07K16/08;C12N7/00;C07K14/005;A61K39/42;A61K45/06 |
主分类号 |
C07K16/08 |
代理机构 |
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代理人 |
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主权项 |
1. A human monoclonal antibody or an antigen binding fragment thereof which is capable of binding to a polyomavirus and/or antigen thereof. |
地址 |
Schlieren CH |