Piperidinyl monocarboxylic acids as S1P1 receptor agonists

摘要

The present invention relates to novel compounds acting as agonists at S1P (sphingosine-1-phosphate) receptors, compositions containing these compounds, use of these compounds in medicine and their process of preparation.;

主权项

1. A compound of formula (I): wherein: Ar is a phenyl group optionally substituted by one or more identical or different group(s) selected from the group consisting of halogen, alkyl, cycloalkyl, —Oalkyl, and phenyl; R1 represents —X—(Y)n— where
—X— is selected from the group consisting of -alkyl-, -alkenyl-, -alkynyl-, -aryl-, and -alkylaryl-,each Y, identical or different is selected from the group consisting of H, OH, halogen, —Oalkyl, —Oalkylaryl, —OalkylOalkyl, —Oaryl, heteroaryl, —Oaryl(Oalkyl), —Ocycloalkyl, -cycloalkyl, and heterocyclyl;n is 1 to 3; and where R1 is not —C(═O)OH; and R2 is H or alkyl; or one of its stereoisomers or salts thereof.