| 摘要 |
The invention provides an amphiphilic siloxane-containing (meth)acrylamide which comprises one sole (meth)acrylamido group, one sole tris(trimethylsiloxy)silyl group, and one polyethylene glycol segment which is either dangling polymer chain or a hydrophilic linker between the (meth)acrylamido group and the tris(trimethylsiloxy)silyl group. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing (meth)acrylamido group, one tris(trimethylsiloxy)silyl group of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an amphiphilic siloxane-containing (meth)acrylamido group, one tris(trimethylsiloxy)silyl group of the invention and/or an actinically-crosslinkable silicone -containing prepolymer of the invention. |
| 主权项 |
1. A method for making silicone hydrogel contact lenses, comprising the steps of: introducing a lens-forming formulation into a mold for making contact lenses, wherein the lens-forming formulation comprises
(a) a solvent selected from the group consisting of water, 1,2-propylene glycol, a polyethyleneglycol having a molecular weight of about 400 Daltons or less, and mixtures thereof, (b) at least one amphiphilic siloxane-containing (meth)acrylamide of formula (1) or (2) in which
A1, A2, A3 and A4 independent of one another are a C1-C6 alkyl, phenyl or benzyl,r1 is an integer of 2 or 3,R′ is H or C1-C4 alkyl,R10 is hydrogen or methyl,R11 is a linear or branched C2-C6 alkylene divalent radical which may be substituted with one or more hydroxyl groups,R12 is C1-C4 alkoxy,Z1 and Z2 independent of each other are a direct bond or a linear or branched C1-C4 alkylene divalent radical,Z3 is C2-C4 alkylene divalent radical,Z4, Z5, and Z6 independent of one another are a direct bond or a linear or branched C1-C20 alkylene divalent radical which may have one or more ether, thio, amine, carbonyl, or amido linkages in their main chain,X1 is —O—CO—NH— or —O—CO—NH—R13—NH—CO—O— in which R13 is a linear or branched C2-C12 alkylene divalent radical or a C5-C45 cycloaliphatic or aliphatic-cycloaliphatic divalent radical,X2 and X3 independent of each other are selected from the group consisting of direct bond, —O—, —NR′—, —CO—NR′—, —NR′—CO—, —O—CO—NH—, —NH—CO—O—, —NR′—CO—NH—, —NH—CO—NR′—, —S—CO—NH—, —NH—CO—S—, —S—, —CO—O—, —O—CO—, —O—CO—NH—R13—NH—CO—O—, and —NH—CO—NH—R13—NH—CO—NH—, in which R′ and R13 are as defined above, q1 is an integer from 2 to 50, q2 is an integer from 3 to 20, (c) at least one hydrophilic vinylic monomer, and (d) at least one component selected from the group consisting of a hydrophilized polysiloxane-containing crosslinker, a hydrophilic crosslinker, a photoinitiator, a thermal initiator, a UV-absorbing vinylic monomer, a visibility tinting agent, an antimicrobial agent, a bioactive agent, a leachable lubricant, a leachable tear-stabilizing agent, and mixtures thereof; polymerizing the lens-forming formulation in the mold to form a silicone hydrogel contact lens, wherein the formed silicone hydrogel contact lens has a water content of from about 20% to about 75% by weight when fully hydrated, an oxygen permeability (Dk) of at least about 40 barrers, and an elastic modulus of from about 0.1 MPa to about 2.0 MPa. |
