| 发明名称 |
ANTI-KIR3D ANTIBODIES |
| 摘要 |
The present invention provides antigen-binding proteins capable of binding to KIR3D polypeptides. The antibodies have increased activity in the treatment of disorders characterized by KIR3DL2-expressing cells, particularly CD4+ T cells, including malignancies such as Mycosis Fungoides and Sézary Syndrome. |
| 申请公布号 |
US2016046713(A1) |
申请公布日期 |
2016.02.18 |
| 申请号 |
US201514924786 |
申请日期 |
2015.10.28 |
| 申请人 |
INNATE PHARMA |
发明人 |
ANFOSSI NICOLAS;GAUTHIER LAURENT;MOREL YANNIS;MORETTA ALESSANDRO;PAROLINI SILVIA;ROSSI BENJAMIN |
| 分类号 |
C07K16/28;A61K45/06;A61K39/395 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated antibody that specifically binds to an epitope within the KIR3DL2 domain 0 having the amino acid sequence of SEQ ID NO: 21, wherein said antibody inhibits proliferation of KIR3DL-expressing human T lymphocytes and comprises a constant region of human IgG isotype. |
| 地址 |
MARSEILLE FR |
