发明名称 |
Piperazinotrizole compound, preparation method therefor, and use thereof in drug preparation |
摘要 |
Provided is a piperazinotrizole compound represented by general formula I or an isomer, a pharmaceutically acceptable salt, ester, prodrug or hydrate thereof. Also provided are a method for preparing the compound, a drug composition containing the compound, and a use thereof as a high-selectivity poly(ADP-ribose) polymerase-1 (PARP1) inhibitor in the preparation of drugs for the prevention and/or treatment of PARP-related diseases. |
申请公布号 |
AU2013299117(B2) |
申请公布日期 |
2016.02.18 |
申请号 |
AU20130299117 |
申请日期 |
2013.07.24 |
申请人 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES |
发明人 |
ZHANG, AO;MIAO, ZEHONG;YE, NA;HUAN, XIAJUAN;SONG, ZILAN;CHEN, CHUANHUIZI;CHEN, YI;DING, JIAN |
分类号 |
C07D487/04;A61K31/4985;A61K31/501;A61K31/502;A61P9/10;A61P25/28;A61P35/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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