INHIBITORS OF PRMT5 AND METHODS OF THEIR USE

摘要

In one aspect, the invention relates to PRMT5 inhibitors, including optionally substituted N-alkyl-9H-carbazole analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation and benign hematologic diseases using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

主权项

1. A compound, or pharmaceutically acceptable salt thereof, having a structure represented by a formula: wherein R1 is C1-C4 alkyl; wherein R2 is selected from hydrogen, fluoro, chloro, and bromo; wherein R3 is selected from C1-C4 alkyl, —NH2, —NHCH3, and —N(CH3)2; and wherein: (a) L is and Ar is provided that R2 is fluoro, chloro, or bromo, or Ar is or (b) L is and Ar is provided that R2 is fluoro, chloro, or bromo, or Ar is or (c) L is and Ar is (d) L is and Ar is or Ar is provided that R3 is C1-C4 alkyl; or (e) L is and Ar is provided that R2 is fluoro, chloro, or bromo, or Ar is provided that R3 is C1-C4 alkyl.