发明名称 |
AMYOTROPHIC LATERAL SCLEROSIS AND/OR FRONTOTEMPORAL LOBAR DEGENERATION MODEL MOUSE |
摘要 |
To generate a mouse model exhibiting symptoms similar to those of human amyotrophic lateral sclerosis and/or human frontotemporal lobar degeneration. A mouse model exhibiting symptoms similar to those of human amyotrophic lateral sclerosis and/or human frontotemporal lobar degeneration can be produced by means of generating a mutation in a vertebrate so that expression of a mutant protein with a substitution of tyrosine for alanine at a position corresponding to position 382 of SEQ ID NO. 1 or a mutant protein with a substitution of cysteine for glycine at a position corresponding to position 348 of SEQ ID NO. 1 is regulated by an endogenous TDP-43 gene promoter in at least one allele of an endogenous TDP-43 gene of the vertebrate. |
申请公布号 |
EP2856869(A4) |
申请公布日期 |
2016.02.17 |
申请号 |
EP20130796611 |
申请日期 |
2013.05.30 |
申请人 |
KEIO UNIVERSITY |
发明人 |
OKANO, HIDEYUKI;OKANO, JAMES HIROTAKA;MIYAUCHI, CHIKAKO |
分类号 |
A01K67/027;C12N15/09 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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