| 摘要 |
Disclosed herein are methods for identifying compounds that enhance base excision repair, as well as compounds identified thereby and methods of using such compounds in the interception of malignancy, i.e. the prevention of progression of a disease from a state of susceptibility to active disease. Exemplified compounds are acetohexamide and related compounds, as well as benserazide and analogs thereof. Exemplified malignancies are those of human breast cells carrying mutations, in particular, SUM149 cells and HCC1937 cells, which cells carry BRCA1 mutations. |
| 主权项 |
1. A method of preventing malignancy in a subject having a genetic predisposition to such malignancy, comprising the step of administering to said subject an effective amount of a DNA repair agent which is a compound selected from the group consisting of bepridil hydrochloride, ancitabine hydrochloride, cytosine-1-beta-D-arabinofuranoside hydrochloride, 5-bromo-2′-deoxyuridine, cyclosporin A, cantharidin, bretylium tosylate, 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride, glipizide, benserazide hydrochloride, mitoxantrone, (+)-brompheniramine maleate, acetohexamide, cyproterone acetate, calcimycin, clotrimazole, captopril, L-p-chlorophenylalanine methyl ester hydrochloride, and centrophenoxine hydrochloride. |
