主权项 |
1. An bis-β-carboline compound and a pharmaceutical salt thereof are described as general formula Iwherein,
R1 is substituent selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 linear or branched alkyl, hydroxyl, substituted or unsubstituted C1-6 linear or branched alkoxy, sulfonate group, substituted or unsubstituted C1-6 linear or branched alkylthio, C1-6 alkoxy C1-6 alkyl group, amino group, substituted or unsubstituted C1-6 linear or branched alkylamino group wherein the alkylamino group include mono- and bis-alkylamino, halogen, nitro, cyano, substituted or unsubstituted five-six membered aryl, substituted or unsubstituted five-six membered aryl containing 1-4 heteroatoms selected from N, O, or S; Substituents on the substituted or unsubstituted five-six membered aryl are selected from the group consisting of hydroxy, mercapto, amino, aldehyde, carboxyl, carbamoyl, halogen, nitro, cyano, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylamino, C1-6 alkylamino group and C1-6 alkoxy C1-6 alkyl group; Substituents on the substituted or unsubstituted five-six membered aryl containing 1-4 heteroatoms selected from N, O, or S; are selected from the group consisting of hydroxy, mercapto, amino, aldehyde, carboxyl, carbamoyl, halogen, nitro, cyano, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylamino, C1-6 alkylamino group and C1-6 alkoxy C1-6 alkyl group; R3 is substituent selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 linear or branched alkyl carconby, carboxyl; substituted or unsubstituted C1-6 linear or branched alkoxy carconby, substituted or unsubstituted C1-6 linear or branched alkyl carbonyloxy, amino-carbonyl, substituted or unsubstituted C1-6 linear or branched alkylamino carbonyloxy, substituted or unsubstituted C1-6 linear or branched alkyl acyl amido; R6 is substituent selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 linear or branched alkyl, hydroxyl, substituted or unsubstituted C1-6 linear or branched alkoxy, sulfonate group, substituted or unsubstituted C1-6 linear or branched alkylthio, C1-6 alkoxy C1-6 alkyl group, amino group, substituted or unsubstituted C1-6 linear or branched alkylamino group wherein the alkylamino group include mono- and bis-alkylamino, aldehyde, substituted or unsubstituted C1-6 linear or branched alkyl acyl, substituted or unsubstituted C1-6 linear or branched alkyloxy acyl, carboxyl, substituted or unsubstituted C1-6 linear or branched alkyl acyloxy, carbamoyl, substituted or unsubstituted C1-6 linear or branched alkyl acylamino group, substituted or unsubstituted C1-6 linear or branched alkyl acylamino group, C2-6 olefins, halogen, nitro, cyano; R7 is substituent selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 linear or branched alkyl, hydroxyl, substituted or unsubstituted C1-6 linear or branched alkoxy, sulfonate group, substituted or unsubstituted C1-6 linear or branched alkylthio, C1-6 alkoxy C1-6 alkyl group, amino group, substituted or unsubstituted C1-6 linear or branched alkylamino group wherein the alkylamino group include mono- and bis-alkylamino, aldehyde, substituted or unsubstituted C1-6 linear or branched alkyl acyl, substituted or unsubstituted C1-6 linear or branched alkyloxy acyl, carboxyl, substituted or unsubstituted C1-6 linear or branched alkyl acyloxy, carbamoyl, substituted or unsubstituted C1-6 linear or branched alkyl acylamino group, substituted or unsubstituted C1-6 linear or branched alkyl acylamino group, C2-6 olefins, halogen, nitro, cyano; R8 is substituent selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 linear or branched alkyl, hydroxyl, substituted or unsubstituted C1-6 linear or branched alkoxy, sulfonate group, substituted or unsubstituted C1-6 linear or branched alkylthio, C1-6 alkoxy C1-6 alkyl group, amino group, substituted or unsubstituted C1-6 linear or branched alkylamino group wherein the alkylamino group include mono- and bis-alkylamino, aldehyde, substituted or unsubstituted C1-6 linear or branched alkyl acyl, substituted or unsubstituted C1-6 linear or branched alkyloxy acyl, carboxyl, substituted or unsubstituted C1-6 linear or branched alkyl acyloxy, carbamoyl, substituted or unsubstituted C1-6 linear or branched alkyl acylamino group, substituted or unsubstituted C1-6 linear or branched alkyl acylamino group, C2-6 olefins, halogen, nitro, cyano; Substituents on the substituted or unsubstituted C1-6 linear or branched alkyl are selected from the group consisting of hydroxy, mercapto, amino, aldehyde, carboxyl, carbamoyl, halogen, nitro, and cyano; n is selected from the group consisting of the natural numbers from 2 to 12. |