发明名称 POLYMERIC ANTIBIOTICS
摘要 The disclosure provides, inter alia, polymeric antibiotic compounds such as modified chitosans and methods of use thereof.
申请公布号 US2016038601(A1) 申请公布日期 2016.02.11
申请号 US201514823930 申请日期 2015.08.11
申请人 The Regents of the University of California 发明人 Kwon Young Jik;Edson Julius
分类号 A61K47/48;A61K31/7088 主分类号 A61K47/48
代理机构 代理人
主权项 1. A polymeric compound of Formula (I): wherein: each Y is independently: —NH2, —NH—C(═O)CH3, ora protecting group; each X is independently: —OH, —O—C(R1R2)—O—(CH2—CH2—O)x—(CH2)y—R3, or—O—C(R1R2)—O-D; orprovided that at least one X is not —OH; p is 2 or more; x and y are each independently an integer from 1 to 10; each T is independently a terminal moiety; R1 and R2 are each independently H, a substituted C1-6 alkyl group, an unsubstituted C1-6 alkyl group, a substituted C5-6 heteroalkyl group, or an unsubstituted C5-6 heteroalkyl group; R3 is —NH2, —C(═O)—R4, or —NH2—C(═O)—R4; and R4 is D, a C1-6 alkyl group, or a C1-6 alkyl group substituted with one or more halogen atoms; and D is a drug moiety.
地址 Oakland CA US