发明名称 |
Profármacos de pirimidinas que inhiben la replicación del VIH |
摘要 |
The present invention concerns compounds of formula (A1)(A2)N—R1 (I), the N-oxide forms, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R1 is substituted C1-6alkyl; —S(═O)—R8; —S(═O)2—R8; C7-12alkylcarbonyl; optionally substituted C1-6alkyloxycarbonylC1-6alkylcarbonyl; with R8 being C1-6alkyl, aryl1 or Het1; (A1)(A2)N— is the covalently bonded form of the corresponding intermediate of formula (A1)(A2)N—H, which is a HIV replication inhibiting pyrimidine of formula |
申请公布号 |
ES2559273(T3) |
申请公布日期 |
2016.02.11 |
申请号 |
ES20010933925T |
申请日期 |
2001.05.03 |
申请人 |
JANSSEN PHARMACEUTICA NV |
发明人 |
KUKLA, Michael Joseph;LUDOVICI, Donald William;KAVASH, Robert W.;DE CORTE, Bart Lieven Daniel;HEERES, Jan;JANSSEN, Paul Adriaan Jan;KOYMANS, Lucien Maria Henricus;DE JONGE, Marc René;VAN AKEN, Koen Jeanne Alfons;KRIEF, Alain |
分类号 |
C07D239/46;C07D239/47;A61K31/505;A61K31/506;A61K31/5377;A61K45/00;A61K47/48;A61P31/18;A61P43/00;C07D239/48;C07D401/12;C07D403/12 |
主分类号 |
C07D239/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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