发明名称 |
POTENTIATING ANTIBODY-INDUCED COMPLEMENT-MEDIATED CYTOTOXICITY VIA PI3K INHIBITION |
摘要 |
Methodologies and technologies for potentiating antibody-based cancer treatments by increasing complement-mediated cell cytotoxicity are disclosed. Further provided are methodologies and technologies for overcoming ineffective treatments correlated with and/or caused by sub-lytic levels of complement-activating monoclonal antibodies (“mAb”) against cancer antigens or cancer antigens with low tumor cell density. While detectable levels of passively administered or vaccine-induced mAb against some antigens are able to delay or prevent tumor growth, low levels of mAb induce sublytic levels of complement activation and accelerate tumor growth. This complement-mediated accelerated tumor growth initiated by low mAb levels results in activation of the PI3K/AKT survival pathway. Methodologies and technologies relating to administration of PI3K inhibitors to overcome low dose mAb-initiated, complement-mediated PI3K activation and accelerated tumor growth are disclosed. |
申请公布号 |
EP2827903(A4) |
申请公布日期 |
2016.02.10 |
申请号 |
EP20130764228 |
申请日期 |
2013.03.14 |
申请人 |
MEMORIAL SLOAN KETTERING CANCER CENTER |
发明人 |
WU, XIAOHONG;SCHOLZ, WOLFGANG, W.;RAGUPATHI, GOVIND;LIVINGSTON, PHILIP, O. |
分类号 |
A61K39/395;A61K31/4375;A61K31/4745;A61K31/5377;A61K39/00;A61K39/385;A61K39/39;A61P35/00;C07K16/28;C07K16/30;C12Q1/68;G01N33/574 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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