Systems and methods for an integrated bio-entity manipulation and processing device

摘要

An integrated semiconductor device for manipulating and processing bio-entity samples is disclosed. The device includes a microfluidic channel formed between a first substrate and a second substrate and a microfluidic grid formed over the first substrate and coupled to the microfluidic channel to manipulate a droplet within the microfluidic channel. The device further includes a magnetic field generation device included in the microfluidic grid and fluidic control circuitry coupled to the magnetic device to facilitate control of the magnetic field generation device to manipulate the droplet, when the droplet contains at least one magnetic bead, within the microfluidic channel.

主权项

1. A device comprising:
a microfluidic channel formed between a first substrate and a second substrate configured to receive a droplet therein; a microfluidic grid formed over the first substrate and coupled to the microfluidic channel, the microfluidic grid comprising a plurality of electrodes; a magnetic field generation device included in the microfluidic grid, wherein the magnetic field generation device is positioned within an opening in one of the plurality of electrodes; and fluidic control circuitry coupled to the magnetic field generation device to facilitate control of the magnetic field generation device to manipulate the droplet when the droplet is present and contains at least one magnetic tag within the microfluidic channel.