| 发明名称 | Lytic domain fusion constructs and methods of making and using same | ||
| 摘要 | The invention relates to fusion constructs, methods of using fusion constructs and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies. | ||
| 申请公布号 | US9255134(B2) | 申请公布日期 | 2016.02.09 |
| 申请号 | US201314038631 | 申请日期 | 2013.09.26 |
| 申请人 | Esperance Pharmaceuticals, Inc.;Board of Supervisors of Louisana State University and Agricultural and Mechanical College | 发明人 | Leuschner Carola;Alila Hector |
| 分类号 | C07K14/59;C07K7/08;A61K38/24;A61K45/06 | 主分类号 | C07K14/59 |
| 代理机构 | Pillsbury Winthrop Shaw Pittman LLP | 代理人 | Pillsbury Winthrop Shaw Pittman LLP |
| 主权项 | 1. A fusion construct comprising a first lytic domain and a second domain, wherein said first lytic domain consists of peptide KFAKFAKKFAKFAKK (SEQ. ID NO. 1) or peptide KFAKFAKKFAKFAKKFAK (SEQ. ID NO. 4); and said second domain comprises a luteinizing hormone releasing hormone (LHRH), an LHRH fragment, or an LHRH analog. | ||
| 地址 | Baton Rouge unknown | ||