CO-CRYSTALS OF TRAMADOL AND COXIBS

摘要

THE PRESENT INVENTION RELATES TO CO-CRYSTALS OF TRAMADOL AND CO-CRYSTAL FORMERS SELECTED FROM NSAIDS/COXIBS, PROCESSES FOR PREPARATION OF THE SAME AND THEIR USES AS MEDICAMENTS OR IN PHARMACEUTICAL FORMULATIONS, MORE PARTICULARLY FOR THE TREATMENT OF PAIN. IN A PREFERRED EMBODIMENT, THE CO-CRYSTAL IS (RAC) - TRAMADOL. HCL - COLOCOXIB (1:1). (THE MOST ILLUSTRATIVE DRAWING IS