发明名称 |
A DOSING REGIME AND FORMULATIONS FOR TYPE B ADENOVIRUSES |
摘要 |
The present disclosure provides a method of treating a human patient comprising the steps of: systemically administering multiple doses of a parenteral formulation of a replication capable oncolytic adenovirus of subgroup B in a single treatment cycle, wherein the total dose given in each dose is in the range of 1×1010 to 1×1014 viral particles, and wherein each dose of virus is administered over a period of 1 to 90 minutes, for example at a rate of viral particle delivery in the range of 2×1010 particles per minute to 2×1012 particles per minute. The disclosure further extends to formulations of the said oncolytic adenoviruses and combination therapies of the viruses and formulations with other therapeutic agents. |
申请公布号 |
SG11201510064W(A) |
申请公布日期 |
2016.01.28 |
申请号 |
SG11201510064W |
申请日期 |
2014.06.12 |
申请人 |
PSIOXUS THERAUPEUTICS LIMITED |
发明人 |
BEADLE, JOHN, WILLIAM;FISHER, KERRY;WILKINSON BLANC, CHRISTINE |
分类号 |
A61K35/76;A61P35/00 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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