发明名称 |
PRINTABLE MORPHOGENETIC PHASE-SPECIFIC CHITOSAN-CALCIUM-POLYPHOSPHATE SCAFFOLD FOR BONE REPAIR |
摘要 |
This invention concerns a formula for the synthesis of a printable hybrid material, formed of carboxymethyl chitosan (CMC) and polyphosphate (polyP). Both polymers are linked together by calcium ions. The inventive CMC-polyP material, in combination with alginate, is biocompatible, biodegradable and useful for three-dimensional (3D) printing and 3D cell printing (bioprinting). The CMC-polyP scaffold, hardened by exposure to calcium ions, is morphogenetically active and can be used in bone tissue engineering, as a bio mimetic 3 -phase scaffold that mimics and induces essential phases in bone repair, including blood clot formation and platelet degranulation (release of growth factors and cytokines) (Phase 1: initiation phase), calcium carbonate bioseed formation (Phase 2: nucleation) and expression / activation of bone alkaline phosphatase (Phase 3: hydroxyapatite - biomineral formation). |
申请公布号 |
WO2016012583(A1) |
申请公布日期 |
2016.01.28 |
申请号 |
WO2015EP66979 |
申请日期 |
2015.07.24 |
申请人 |
MÜLLER, WERNER ERNST LUDWIG GEORG;SCHRÖDER, HEINRICH-CHRISTOPH WILHELM FRIEDRICH;WANG, XIAOHONG |
发明人 |
MÜLLER, WERNER ERNST LUDWIG GEORG;SCHRÖDER, HEINRICH-CHRISTOPH WILHELM FRIEDRICH;WANG, XIAOHONG |
分类号 |
A61L27/20;A61L27/46;A61L27/52;A61L27/56;A61L27/58;C08L5/08 |
主分类号 |
A61L27/20 |
代理机构 |
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